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Tacrolimus与肾功能不全

Tacrolimus与肾功能不全安全配伍检测的结果。

检测结果:

Tacrolimus <> 肾功能不全

现实性: 23.07.2019 评论家: 医学副博士Shkutko P.M., in

通过权威的信息来源 Drugs.com、Rxlist.com、Webmd.com、Medscape.com，在进行所选药物与这种伴发疾病互相作用检测时，发现一些会产生负面影响或对身体危害的禁忌症及副作用。

用户:

肾毒性已经报告在52%的肾和40%的肝脏移植的患者。肾脏毒性包括提高血清肌酸酐和血尿素氮和肾功能衰竭，有时需要血液透析。少尿和尿血还有报道。该机制的藤致肾功能障碍是没有很好确立。肾脏毒性的出现与剂量有关，虽然毒性仍然可能发生，甚至在建议的治疗浓度。治疗与藤应给予谨慎和剂量的减少可能是必要的，在患者与受到损害肾功能。替代治疗免疫抑制应被认为是在存在持续或恶化的肾功能障碍。

来源

McCauley J, Takaya S, Fung J, et al "The question of FK 506 nephrotoxicity after liver transplantation." Transplant Proc 23 (1991): 1444-7
Platz KP, Mueller AR, Blumhardt G, Bachmann S, Bechstein WO, Kahl A, Neuhaus P "Nephrotoxicity following orthotopic liver transplantation - a comparison between cyclosporine and FK506." Transplantation 58 (1994): 170-8
Fries D, Rucay P, Samuel D, Hiesse C, Meduri G, Callard P, Fredj G, Bismuth H "Development of renal dysfunction and renal histological lesions in two patients treated with FK 506 for acute rejection following liver transplantation." Transplant Proc 23 (1991): 3099-100
Porayko MK, Textor SC, Krom RA, Hay JE, Gores GJ, Richards TM, Crotty PH, Beaver SJ, Steers JL, Wiesner RH "Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation." Mayo Clin Proc 69 (1994): 105-11
Winkler M, Jost U, Ringe B, Gubernatis G, Wonigeit K, Pichlmayr R "Association of elevated FK 506 plasma levels with nephrotoxicity in liver-grafted patients." Transplant Proc 23 (1991): 3153-5
Sumpio BE, Phan S "Nephrotoxic potential of FK 506." Transplant Proc 23 (1991): 2789-90
"Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.

Tacrolimus

非专利名称: tacrolimus

品牌: Astagraf XL, Envarsus XR, Prograf, Hecoria

同义词: Tacrolimus (oral and injection), Tacrolimus (Systemic)

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