根据名称进行药物检索

Acetaminophen, Aspirin, Caffeine, and Salicylamide Tablets与胃肠道毒性

Acetaminophen, Aspirin, Caffeine, and Salicylamide Tablets与胃肠道毒性安全配伍检测的结果。

检测结果:

Acetaminophen, Aspirin, Caffeine, and Salicylamide Tablets <> 胃肠道毒性

现实性: 23.07.2019 评论家: 医学副博士Shkutko P.M., in

通过权威的信息来源 Drugs.com、Rxlist.com、Webmd.com、Medscape.com，在进行所选药物与这种伴发疾病互相作用检测时，发现一些会产生负面影响或对身体危害的禁忌症及副作用。

用户:

水杨酸，特别是阿司匹林，可能造成的剂量相关的消化道出血和粘膜的损害，这可能出现的相互独立。神秘，往往无症状的GI失血相当常见的，与往常一样剂量的阿司匹林和来自这种药物的地方效果上胃肠粘膜。在慢性治疗，这种类型的出血可能会偶尔产生的缺铁性贫血。与此相反，主要的上消化道出血情况很少发生，除非在患者与活动的胃溃疡，或最近的GI出血。然而，这些病人通常不会遇到更大的神秘血液损于健康的病人以下的小剂量的阿司匹林。粘膜的损坏相关联的用水杨酸盐可能导致发展为胃溃疡有或没有流血，重新激活的潜溃疡和胃溃疡穿孔。治疗与水杨酸盐和相关代理诸如水杨酰胺应该予以考虑，并给予谨慎的患者的历史GI疾病或酗酒，尤其是如果他们是老年人和/或衰弱，因为这样的病人可以更容易受到胃肠毒性的这些药物，似乎容忍溃疡出血不太好，比其他个人。极为谨慎并透彻评估的风险和益处是必要的患者活动或最近的消化道出血或损害。只要有可能，特别是如果长时间使用的是预期的治疗与非溃疡的药剂应该尝试的第一个。如果水杨酸盐的使用，密切监测用于毒性建议。一些不利的GI影响可能最小化的行政当局与高剂量的抗酸剂、利用肠衣或缓释制剂，和/或同时使用的一个组胺H2-受体拮抗剂或细胞保护剂，如米索前列醇. 患有消化性活动溃疡，或者消化道出血处理与水杨酸一般应给予一个伴随的反溃疡治疗方案。

来源

Lanas A, Serrano P, Bajador E, Esteva F, Benito R, Sainz R "Evidence of aspirin use in both upper and lower gastrointestinal perforation." Gastroenterology 112 (1997): 683-9
Savon JJ, Allen ML, Dimarino AJ, Hermann GA, Krum RP "Gastrointestinal blood loss with low dose (325 mg) plain and enteric-coated aspirin administration." Am J Gastroenterol 90 (1995): 581-5
"Product Information. Salflex (salsalate)." Carnrick Laboratories Inc, Cedar Knolls, NJ.
American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
Stalnikowiczdarvasi R "Gastrointestinal bleeding during low-dose aspirin administration for prevention of arterial occlusive events: a critical analysis." J Clin Gastroenterol 21 (1995): 13-6
Roderick PJ, Wilkes HC, Meade TW "The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials." Br J Clin Pharmacol 35 (1993): 219-26
Bergmann JF, Chassany O, Geneve J, Abiteboul M, Caulin C, Segrestaa JM "Endoscopic evaluation of the effect of ketoprofen, ibuprofen and aspirin on the gastroduodenal mucosa." Eur J Clin Pharmacol 42 (1992): 685-8
"Product Information. Ecotrin (aspirin)." SmithKline Beecham, Philadelphia, PA.
Wilcox CM, Shalek KA, Cotsonis G "Striking prevalence of over-the-counter nonsteroidal anti- inflammatory drug use in patients with upper gastrointestinal hemorrhage." Arch Intern Med 154 (1994): 42-6
Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K "Adverse effects of low-dose aspirin in a healthy elderly population." Clin Pharmacol Ther 54 (1993): 84-9
Sabesin SM, Boyce HW Jr, King CE, Mann JA, Ruoff G, Wall E "Comparative evaluation of gastrointestinal intolerance produced by plain and tri-buffered aspirin tablets." Am J Gastroenterol 83 (1988): 1220-5
Greenberg PD, Cello JP, Rockey DC "Asymptomatic chronic gastrointestinal blood loss in patients taking aspirin or warfarin for cardiovascular disease." Am J Med 100 (1996): 598-604
Levy M, Miller DR, Kaufman DW, Siskind V, Schwingl P, Rosenberg L, Strom B, Shapiro S "Major upper gastrointestinal tract bleeding. Relation to the use of aspirin and other nonnarcotic analgesics." Arch Intern Med 148 (1988): 281-5
Marks RD "Aspirin use and fecal occult blood testing." Am J Med 100 (1996): 596-7
Mehta S, Dasarathy S, Tandon RK, Mathur M, Malaviya AN "A prospective randomized study of the injurious effects of aspirin and naproxen on the gastroduodenal mucosa in patients with rheumatoid arthritis." Am J Gastroenterol 87 (1992): 996-1000
Naschitz JE, Yeshurun D, Odeh M, Bassan H, Rosner I, Stermer E, Levy N "Overt gastrointestinal bleeding in the course of chronic low-dose aspirin administration for secondary prevention of arterial occlusive disease." Am J Gastroenterol 85 (1990): 408-11
Weil J, Colinjones D, Langman M, Lawson D, Logan R, Murphy M, Rawlins M, Vessey M, Wainwright P "Prophylactic aspirin and risk of peptic ulcer bleeding." BMJ 310 (1995): 827-30
Graham DY, Smith JL "Aspirin and the stomach." Ann Intern Med 104 (1986): 390-8
Prichard PJ, Kitchingman GK, Walt RP, Daneshmend TK, Hawkey CJ "Human gastric mucosal bleeding induced by low dose aspirin, but not warfarin." BMJ 298 (1989): 493-6